The Holiday Inn City Centre was, for us, a last resort. We chose it because it provided the most value (though we still couldn't get rates below €130 - heard it's much cheaper at weekends), but it turned out to be worth the money.
Firstly, although we requested a non-smoking room, and did get one, our room had an overpowering smell of tobacco, but when we asked to be moved, our keycard was immediately changed and within 5 minutes we were moved a couple of doors down in a new, fresh room.
The hotel is currently "undergoing some refurbishment" so we were warned that our rooms may be below the standard we expected. However, everything was fine! Clean, large rooms, nice bathrooms and BBC One on the telly, as you find with all Belgian hotels. The decor is slightly off-modern (with that I mean it's far from white linen and chrome) but gives lovely soft beds and a pillow menu (god bless Holiday Inn for that idea - I can't sleep without an extra pillow)
The hotel's location is NOT central. If you don't like walking and expect to be able to walk out of your hotel into tourist paradise, expect otherwise. However, 4 minutes down the road is the Place Stéphanie tram stop that provides an easy link for €1,50 into the centre - took about 5 minutes, we were told it was a 20 minute walk. The nearest metro station is an 8-minute walk at Louise, so for other parts of the city, this is easily accessible and easy to use - you can even use the tram if you're not up to the walk and have a travelcard.
The hotel's breakfast (if not included in your room rate) is worth missing - €20 for murky coffee and slow service, but if it's included, it's a sufficiently good start to the day - pastries, juice, toast, cheese, eggs and bacon.
The hotel is in a very safe neighbourhood of town - no graffiti in sight and near some nice restaurants if you start walking town the Avenue Louise and near some very fashionable (and expensive) boutiques.
Overall, if you can get a good rate, go for it, but you can get a much more central hotel. The hotel's nothing to rave about, but provides everything you need.
This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC.