The Prince Garden Meguro is by far most convenient. Meguro Station is on the Yamanote Loop Line that circles central Tokyo. This line takes you to many happening places, such as Shinjuku and Shibuya in a short time without a transfer.

Meguro is also convenient to Roppongi Itchome Station.

Which one did you choose and what was it like? I am facing the same question. Thanks

I ended up staying at Akasaka Yoko Hotel, which is in Akasaka - close to the Roppongi area. It was a five minute walk to the closest station, so it's very convenient. I booked it through asiarooms: asiarooms.com/japan/tokyo/akasaka_yoko.html

Nice place -only bad thing was that the bathroom was a bit small, but I guess that's normal for Japan, from what I've heard anyway..

Would absolutely recommend this hotel.

But to answer the question about what area; I wouldn't stay in Asakusa, as it is a bit far out. Shinagawa would be your best out of those three, since it's on the Yamanote line.

Wow, Akasaka Yoko brings back some memories. I think I stayed there in '86 during the bubble. Our office was in the towers above Akasaka subway station down the street across from TBS. I too wouldn't recommend it to anyone because of the location. It's just too far away from everything compared to other options.

So teetravel, what did you end up deciding? I too am pondering and facing the same decision.